George F. Njoroge: search on Z-Library

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1

Quantitation of branched-chain α-keto acids as their N-methylquinoxalone derivatives: Comparison of O- and N-alkylation versus -silylation

Albert A. Fernandes, Satish C. Kalhan, F. George Njoroge, Gail S. Matousek

Journal:

Biological Mass Spectrometry = Journal of Mass Spectrometry (Wiley)

Year:

1986

Language:

english

File:

PDF, 837 KB

english, 1986

2

N-(Trifluoroacetyl)-.alpha.-amino acid chlorides as chiral reagents for Friedel-Crafts synthesis

Nordlander, J. Eric, Njoroge, F. George, Payne, Mark J., Warman, Dhiraj

Journal:

Journal of Organic Chemistry

Year:

1985

Language:

english

File:

PDF, 566 KB

english, 1985

3

Friedel-Crafts acylation with N-(trifluoroacetyl)-.alpha.-amino acid chlorides. Application to the preparation of .beta.-arylalkylamines and 3-substituted 1,2,3,4-tetrahydroisoquinolines

Nordlander, J. Eric, Payne, Mark J., Njoroge, F. George, Balk, Michael A., Laikos, George D., Vishwanath, Vasanth M.

Journal:

Journal of Organic Chemistry

Year:

1984

Language:

english

File:

PDF, 619 KB

english, 1984

4

(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5 H -benzo[5,6]cyclohepta[1,2- b ]- pyridin-11( R )-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336): A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor Agent

Njoroge, F. George, Taveras, Arthur G., Kelly, Joseph, Remiszewski, Stacy, Mallams, Alan K., Wolin, Ronald, Afonso, Adriano, Cooper, Alan B., Rane, Dinananth F., Liu, Yi-Tsung, Wong, Jesse, Vibulbhan,

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 404 KB

english, 1998

5

Structure−Activity Relationship of 3-Substituted N -(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11 H -benzo[5,6]cyclohepta[1,2- b ]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds

Njoroge, F. George, Vibulbhan, Bancha, Rane, Dinananth F., Bishop, W. Robert, Petrin, Joanne, Patton, Robert, Bryant, Mathew S., Chen, K.-J., Nomeir, Amin A., Lin, C.-C., Liu, Ming, King, Ivan, Chen,

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 411 KB

english, 1997

6

Macrocyclic inhibitors of HCV NS3 protease

Venkatraman, Srikanth, Njoroge, F George

Journal:

Expert Opinion on Therapeutic Patents

Year:

2009

Language:

english

File:

PDF, 1.40 MB

english, 2009

7

Community knowledge and perceptions on malaria prevention and house screening in Nyabondo, Western Kenya

Ng’ang’a, Peter Njoroge, Mutunga, James, Oliech, George, Mutero, Clifford Maina

Journal:

BMC Public Health

Year:

2019

File:

PDF, 1.36 MB

2019

8

Detection of Brucella spp. in raw milk from various livestock species raised under pastoral production systems in Isiolo and Marsabit Counties, northern Kenya

Wainaina, Martin, Aboge, Gabriel O., Omwenga, Isaac, Ngaywa, Catherine, Ngwili, Nicholas, Kiara, Henry, Wamwere-Njoroge, George, Bett, Bernard

Journal:

Tropical Animal Health and Production

Year:

2020

File:

PDF, 681 KB

2020

9

A farnesyl transferase inhibitor suppresses TPA-mediated skin tumor development without altering hyperplasia in the ras transgenic Tg.AC mouse

Carol S. Trempus, W. Robert Bishop, F. George Njoroge, Ronald J. Doll, Michael StJ. Battalora, Joel F. Mahler, Joseph K. Haseman, Raymond W. Tennant

Journal:

Molecular Carcinogenesis

Year:

2000

Language:

english

File:

PDF, 654 KB

english, 2000

10

Proline-Based Macrocyclic Inhibitors of the Hepatitis C Virus: Stereoselective Synthesis and Biological Activity

Kevin X. Chen, F. George Njoroge, Bancha Vibulbhan, Andrew Prongay, John Pichardo, Vincent Madison, Alexei Buevich, Tze-Ming Chan

Journal:

Angewandte Chemie

Year:

2005

Language:

english

File:

PDF, 312 KB

english, 2005

11

Proline-Based Macrocyclic Inhibitors of the Hepatitis C Virus: Stereoselective Synthesis and Biological Activity

Kevin X. Chen, F. George Njoroge, Bancha Vibulbhan, Andrew Prongay, John Pichardo, Vincent Madison, Alexei Buevich, Tze-Ming Chan

Journal:

Angewandte Chemie International Edition

Year:

2005

Language:

english

File:

PDF, 312 KB

english, 2005

12

Syntheses of Novel 4-tert-Alkyl Ether Proline-Based 16- and 17-Membered Macrocyclic Compounds.

Kevin X. Chen, F. George Njoroge, Bancha Vibulbhan, Alexei Buevich, Tze-Ming Chan, Viyyoor Girijavallabhan

Journal:

Year:

2002

File:

PDF, 33 KB

2002

13

Farnesyl Protein Transferase Inhibitors Targeting the Catalytic Zinc for Enhanced Binding.

F. George Njoroge, Bancha Vibulbhan, Patrick Pinto, Corey Strickland, Paul Kirschmeier, W. Robert Bishop, V. Girijavallabhan

Journal:

Year:

2005

File:

PDF, 11 KB

2005

14

Bridgehead Modification of Trihalocycloheptabenzopyridine Lead to a Potent Farnesyl Protein Transferase Inhibitor with Improved Oral Metabolic Stability.

F. George Njoroge, Bancha Vibulbhan, Xiongwei Shi, Corey Strickland, Paul Kirschmeier, Robert Bishop, Amin Nomeir, Viyyoor Girijavallabhan

Journal:

Year:

2005

File:

PDF, 13 KB

2005

15

Synthesis and Biological Activity of Macrocyclic Inhibitors of Hepatitis C Virus (HCV) NS3 Protease.

Kevin X. Chen, F. George Njoroge, Andrew Prongay, John Pichardo, Vincent Madison, Viyyoor Girijavallabhan

Journal:

Year:

2006

File:

PDF, 17 KB

2006

16

ChemInform Abstract: Novel Methods to Functionalize Thiazolo[4,5-c]pyridines.

Vinay Girijavallabhan, Ashok Arasappan, Frank Bennett, Yuhua Huang, F. George Njoroge, Malcolm MacCoss

Journal:

Year:

2010

File:

PDF, 86 KB

2010

17

ChemInform Abstract: The Double Addition Reaction of Alkoxymethyl Nucleophiles to Esters to Generate Novel Polyoxygenated Species.

Vishal A. Verma, Ashok Arasappan, F. George Njoroge

Journal:

Year:

2010

File:

PDF, 23 KB

2010

18

ChemInform Abstract: Regioselective Cobalt-Catalyzed Addition of Sulfides to Unactivated Alkenes.

Vinay Girijavallabhan, Carmen Alvarez, F. George Njoroge

Journal:

Year:

2011

File:

PDF, 40 KB

2011

19

Screening and rank ordering of reversible mechanism-based inhibitors of Hepatitis C virus NS3 protease using electrospray ionization mass spectrometry

Yan-Hui Liu, Lata Ramanathan, Bruce Malcolm, George Njoroge, Tin-Yau Chan, Birendra N. Pramanik

Journal:

Journal of Mass Spectrometry

Year:

2011

Language:

english

File:

PDF, 303 KB

english, 2011

20

A Continuous Spectrophotometric Assay for the Hepatitis C Virus Serine Protease

Rumin Zhang, Brian M. Beyer, James Durkin, Richard Ingram, F.George Njoroge, William T. Windsor, Bruce A. Malcolm

Journal:

Analytical Biochemistry

Year:

1999

Language:

english

File:

PDF, 102 KB

english, 1999

21

Potent ketoamide inhibitors of HCV NS3 protease derived from quaternized P1 groups

Srikanth Venkatraman, Francisco Velazquez, Wanli Wu, Melissa Blackman, Vincent Madison, F. George Njoroge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 656 KB

english, 2010

22

Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue

Kevin X. Chen, Bancha Vibulbhan, Weiying Yang, Kuo-Chi Cheng, Rong Liu, John Pichardo, Nancy Butkiewicz, F. George Njoroge

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 223 KB

english, 2008

23

Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as Hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex

Ashok Arasappan, F. George Njoroge, Tejal N. Parekh, Xiaozheng Yang, John Pichardo, Nancy Butkiewicz, Andrew Prongay, Nanhua Yao, Viyyoor Girijavallabhan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 308 KB

english, 2004

24

Novel inhibitors of the hepatitis C virus NS3 proteinase

Frank Bennett, Yi-Tsung Liu, Anil K. Saksena, Ashok Arasappan, Nancy Butkiewicz, Bimalendu Dasmahapatra, John S. Pichardo, F. George Njoroge, Naginbhai M. Patel, Yuhua Huang, Xiaozheng Yang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 108 KB

english, 2005

25

Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease

Kevin X. Chen, F. George Njoroge, Andrew Prongay, John Pichardo, Vincent Madison, Viyyoor Girijavallabhan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 169 KB

english, 2005

26

Potent inhibitors of HCV-NS3 protease derived from boronic acids

Srikanth Venkatraman, Wanli Wu, Andrew Prongay, Viyyoor Girijavallabhan, F. George Njoroge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 859 KB

english, 2009

27

Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings

Kevin X. Chen, Bancha Vibulbhan, Weiying Yang, Latha G. Nair, Xiao Tong, Kuo-Chi Cheng, F. George Njoroge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.48 MB

english, 2009

28

Potent aza-peptide derived inhibitors of HCV NS3 protease

Srikanth Venkatraman, Wanli Wu, Neng-Yang Shih, F. George Njoroge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.53 MB

english, 2009

29

P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile

Latha G. Nair, Mousumi Sannigrahi, Stephane Bogen, Patrick Pinto, Kevin X. Chen, Andrew Prongay, Xiao Tong, K.-C. Cheng, Viyyoor Girijavallabhan, F. George Njoroge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 2.26 MB

english, 2010

30

Discovery of C-imidazole azaheptapyridine FPT inhibitors

Hugh Y. Zhu, Alan B. Cooper, Jagdish Desai, George Njoroge, Paul Kirschmeier, W. Robert Bishop, Corey Strickland, Alan Hruza, Ronald J. Doll, Viyyoor M. Girijavallabhan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 854 KB

english, 2010

31

Towards the second generation of Boceprevir: Dithianes as an alternative P2 substituent for 2,2-dimethyl cycloproyl proline in HCV NS3 protease inhibitors

Latha G. Nair, Stephane Bogen, Sumei Ruan, Weidong Pan, Russel Pike, Xiao Tong, Kuo-Chi Cheng, Zhuyan Guo, Ronald J. Doll, F. George Njoroge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 2.10 MB

english, 2010

32

Ultra-performance liquid chromatography/tandem mass spectrometric determination of diastereomers of SCH 503034 in monkey plasma

Ganfeng Wang, Yunsheng Hsieh, Kuo-Chi Cheng, Richard A. Morrison, Srikanth Venkatraman, F. George Njoroge, Larry Heimark, Walter A. Korfmacher

Journal:

Journal of Chromatography B

Year:

2007

Language:

english

File:

PDF, 796 KB

english, 2007

33

Novel synthesis of sterically hindered N-substituted lactams from imides

Mousumi Sannigrahi, Patrick Pinto, T.M. Chan, Neng-Yang Shih, F. George Njoroge

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 105 KB

english, 2006

34

Practical and efficient method for amino acid derivatives containing β-quaternary center: application toward synthesis of hepatitis C virus NS3 serine protease inhibitors

Ashok Arasappan, Srikanth Venkatraman, Angela I. Padilla, Wanli Wu, Tao Meng, Yan Jin, Jesse Wong, Andrew Prongay, Viyyoor Girijavallabhan, F. George Njoroge

Journal:

Tetrahedron Letters

Year:

2007

Language:

english

File:

PDF, 323 KB

english, 2007

35

Synthesis of sterically hindered 3,5,5-trimethyl 2,6-dioxo tetrahydro pyrimidine as HCV protease inhibitors

Latha G. Nair, Stephane Bogen, Ronald J. Doll, N.-Y. Shih, F. George Njoroge

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 760 KB

english, 2010

36

Syntheses of 4- and 6-substituted thiazolo[4,5-c]pyridines

Yuhua Huang, Frank Bennett, Vinay Girijavallabhan, Carmen Alvarez, Tze-Ming Chan, Rebecca Osterman, Mary Senior, Cecil Kwong, Namita Bansal, F. George Njoroge, Malcolm MacCoss

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 543 KB

english, 2010

37

Novel methods to functionalize thiazolo[4,5-c]pyridines

Vinay Girijavallabhan, Ashok Arasappan, Frank Bennett, Yuhua Huang, F. George Njoroge, Malcolm MacCoss

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 686 KB

english, 2010

38

Design and synthesis of novel fluoro amino acids: synthons for potent macrocyclic HCV NS3 protease inhibitors

Latha G. Nair, Stephane Bogen, Frank Bennett, Kevin Chen, Bancha Vibulbhan, Yuhua Huang, Weing Yang, Ronald J. Doll, N.-Y. Shih, F. George Njoroge

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 952 KB

english, 2010

39

The double addition reaction of alkoxymethyl nucleophiles to esters to generate novel polyoxygenated species

Vishal A. Verma, Ashok Arasappan, F. George Njoroge

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 781 KB

english, 2010

40

Application of ruthenium induced cyclization for construction of strained biaryl ether macrocyclic compounds

Srikanth Venkatraman, F George Njoroge, Viyyoor Girijavallabhan

Journal:

Year:

2002

Language:

english

File:

PDF, 153 KB

english, 2002

41

Novel tricyclic aminoacetyl and sulfonamide inhibitors of Ras farnesyl protein transferase

F.George Njoroge, Bancha Vibulbhan, Carmen S. Alvarez, W.Robert Bishop, Joanne Petrin, Ronald J. Doll, V. Girijavallabhan, Ashit K. Ganguly

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 275 KB

english, 1996

42

Trihalobenzocycloheptapyridine analogues of Sch 66336 as potent inhibitors of farnesyl protein transferase

F.George Njoroge, Bancha Vibulbhan, Patrick Pinto, Corey L Strickland, W.Robert Bishop, Paul Kirschmeir, V Girijavallabhan, Ashit K Ganguly

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 179 KB

english, 2003

43

Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase

F.George Njoroge, Ronald J. Doll, Bancha Vibulbhan, Carmen S. Alvarez, W.Robert Bishop, Joanne Petrin, Paul Kirschmeier, Nicholas I. Carruthers, Jesse K. Wong, Margaret M. Albanese, John J. Piwinski,

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 1.24 MB

english, 1997

44

Safety and Efficacy of miltefosine alone and in combination with sodium stibogluconate and liposomal amphotericin B for the treatment of primary visceral leishmaniasis in East Africa: study protocol for a randomized controlled trial

Raymond Omollo, Neal Alexander, Tansy Edwards, Eltahir AG Khalil, Brima M Younis, Abuzaid A Abuzaid, Monique Wasunna, Njenga Njoroge, Dedan Kinoti, George Kirigi, Thomas PC Dorlo, Sally Ellis, Manica

Journal:

Year:

2011

Language:

english

File:

PDF, 354 KB

english, 2011

45

Detection of d-glucose-derived pyrrole compounds during maillard reaction under physiological conditions

F. George Njoroge, Lawrence M. Sayre, Vincent M. Monnier

Journal:

Carbohydrate Research

Year:

1987

Language:

english

File:

PDF, 600 KB

english, 1987

46

Farnesyl protein transferase inhibitors targeting the catalytic zinc for enhanced binding

F. George Njoroge, Bancha Vibulbhan, Patrick Pinto, Corey Strickland, Paul Kirschmeier, W. Robert Bishop, V. Girijavallabhan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 368 KB

english, 2004

47

Bridgehead modification of trihalocycloheptabenzopyridine lead to a potent farnesyl protein transferase inhibitor with improved oral metabolic stability

F. George Njoroge, Bancha Vibulbhan, Xiongwei Shi, Corey Strickland, Paul Kirschmeier, Robert Bishop, Amin Nomeir, Viyyoor Girijavallabhan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 301 KB

english, 2004

48

Enhanced FTase activity achieved via piperazine interaction with catalytic zinc

F. George Njoroge, Bancha Vibulbhan, Patrick Pinto, Corey Strickland, W. Robert Bishop, Amin Nomeir, Vivyoor Girijavallabhan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 208 KB

english, 2006

49

Depeptidization efforts on α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity

Stéphane L. Bogen, Sumei Ruan, Rong Liu, Sony Agrawal, John Pichardo, Andrew Prongay, Bahige Baroudy, Anil K. Saksena, Viyyoor Girijavallabhan, F. George Njoroge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 312 KB

english, 2006

50

Novel inhibitors of hepatitis C NS3–NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid

Srikanth Venkatraman, F. George Njoroge, Wanli Wu, Viyyoor Girijavallabhan, Andrew J. Prongay, Nancy Butkiewicz, John Pichardo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 225 KB

english, 2006

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